Nisko was first mentioned in a document dated 15 April 1439, in which King Władysław III of Varna handed the villages of Nysky, Zaoszicze and Pyelaskowicze to a local nobleman.

[3] Due to the location on the edges of the forest, local residents supported themselves by hunting and trade of timber, which was transported to other centers along the San and the Vistula waterways.

From 1868 to 1912 under Count Oliver Rességuier de Miremont and his family, the village grew to become one of the largest estates in then Austrian Galicia.

[5] On 19 January 1937 in Warsaw, a bill was signed, which created Southern Works (Zaklady Poludniowe) – a large steel plant, part of the Central Industrial Region.

It was a milestone in history of the town, because several projects were started in the area, such as a foundry and a power-plant in the forests on the western boundary of Nisko.

[6] As part of the Intelligenzaktion, on November 10, 1939, the Germans deceitfully gathered Polish teachers from the town and its surroundings for a supposed formal meeting, then arrested them and imprisoned them in Rzeszów.

Chief architect of the Holocaust, Adolf Eichmann, set up a transit camp in Nisko, from which the deportees were to be expelled eastward.

[9] In March 1941, the Germans carried out mass arrests of resistance members involved in the distribution of Polish press in Nisko and other nearby towns.