The Nissitissit River begins at the outlet of Potanipo Pond in the town of Brookline, New Hampshire.

It flows southeast at a very mild gradient, crossing the southwest corner of Hollis, New Hampshire, before entering Massachusetts, where it joins the Nashua River in the town of Pepperell.

This article related to a river in New Hampshire is a stub.

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You can help Wikipedia by expanding it.This article related to a river in Massachusetts is a stub.