He acted with Kamal Hassan in a small role in the Tamil comedy film Vasool Raja MBBS, directed by Saran.

Nithin Sathya appeared as the antagonist, a psychopathic villain Rathnavel Kalidas in the critically acclaimed psychological thriller, Satham Podathey (2007), which starred Pritviraj, Padmapriya and Suhasini, and was written and directed by Vasanth.

[3][4] He had his break through when he played the role of Palani in Chennai 600028 by Venkat Prabhu, who is a close associate and friend.

The movie Jarugandi produced by Nithin Satya under his production house Shvedh was released on 26 October 2018.

He played the role of a patient who attempts suicide due to love failure in Saran's 2004 movie Vasool Raja MBBS (2004).

The second film Lock Up is a thriller movie that stars Vaibhav, Venkat Prabhu and Vani Bhojan.

The third film, a romantic comedy starring Mahat Raghavendra and Sana Makbul, titled Kadhal Conditions Apply, was initially scheduled to be released on 15 September 2023.