Nivasorexant (INNTooltip International Nonproprietary Name; developmental code name ACT-539313) is an orexin antagonist medication which is under development for the treatment of binge eating disorder and was previously under development for the treatment of anxiety disorders.

[4][5][6][7][1][2] It is an orally active small-molecule compound with an elimination half-life of 3.3 to 6.5 hours and acts as a selective orexin OX1 receptor antagonist (1-SORA).

[4][1][2] As of May 2022, the drug is in phase 2 clinical trials for binge eating disorder.

[4] Following negative efficacy results of a phase 2 trial of nivasorexant for binge eating disorder, Idorsia (the developer of nivasorexant) signaled in May 2022 that it would not pursue further development of the drug for this indication.

[8] This drug article relating to the nervous system is a stub.