[6] Lyrically, "No Gods No Masters" was inspired by the rebellions against the governments' racism, misogyny and violations of human rights that Manson witnessed in North and South America during the making of Garbage's seventh studio album.

"[7] At the same time, she urges people to remain hopeful about the future and re-imagine a society "not making the same mistakes over and over again and allowing greed to corrupt our thinking.

Live performances of the song recorded at the Mates Rehearsal Studios in North Hollywood were sent to Ouï FM,[10] Rolling Stone France,[11] iHeart Radio[12] and World Cafe[13] to promote the album while keeping social distance during the ongoing COVID-19 pandemic.

The music video of "No Gods No Masters" was directed by Scott Stuckey, produced by Laura Burhenn of Our Secret Handshake and edited by Andy Deluca.

In the blue hue-tinted music video, Manson performs the song wearing a beret, checkered tights and knee-high boots, backed by the rest of the band in a dive bar sporting a "no gods no masters" red neon sign.

[15] Lisa-Marie Ferla of The Arts Desk called the track "epic" and praised its lyrics for channeling "action, not thoughts and prayers, into positive change.

"[22] Peter Piatkowski of PopMatters defined the song as "a speedy swirl of industrial noise, and undulating guitars" and called it "brisk and bracing.