[4] It was written by Giancarlo Bigazzi, Marco Falagiani and Baldi, and was later adapted into Spanish by Ignacio Ballesteros.

[7] The first Spanish version of the song was released by Mexican singer Yuri and her husband Rodrigo Espinoza with different lyrics titled "Hoy Que Estamos Juntos" ("Now That We're Together") on her album Huellas (1997).

Anthony, who had become intrigued by Lopez after seeing her in Selena (1997), came into her studio and asked her to appear in the music video for his song "No Me Conoces".

[27][28] On the year-end charts, "No Me Ames" was the second best-performing Tropical Song of 1999 after "El Niágara en Bicicleta", by Juan Luis Guerra.

[23] The salsa version of the song was featured as a bonus track on the European edition of Lopez's remix album J to tha L–O!

[29][30] The ballad version was featured on Anthony's 2006 compilation album Sigo Siendo Yo: Grandes Exitos.

[31] In her review of On the 6, Heather Phares of Allmusic commented that the tropical version of "No Me Ames" was one of the two songs that "emphasize Lopez's distinctive heritage".

[32] In his review of Desde un Principio: From the Beginning, Jose Promis also from Allmusic praised the song as "surpisingly good".

[29] Mario Tarradell of the Dallas Morning News remarked "No Me Ames" as an "island flavored" song.

[12] Lauri Mascia of the Sun-Sentinel expressed disappointment over the song and felt that the tropical version did not fit the album.

[34] Baldi cited Lopez and Anthony's cover as one of the two that encouraged him to come out of retirement to record another album.

[39] At the inaugural Juventud Awards in 2004, "No Me Ames" was nominated in the category for "La Más Pegajosa" ("Catchiest Tune").

[38] The music video was included on the DVD set for Lopez's compilation album, The Reel Me (2003).

[43] The song was scheduled to be performed at the first annual Latin Grammy Awards, but Anthony was unable to attend due to complications with his wife's pregnancy.

[44] As part of their 2007 co-headlining concert tour, the song was performed as an encore along with "Por Arriesgarnos" after each show.