He is best known for directing the films Smart People, 300: Rise of an Empire, and the BBC miniseries Watership Down.

[4] Along with Shawn Lacy Tessaro, he founded the production company Biscuit Films, which has produced many successful advertising campaigns.

[5] In 2004, he was originally set to direct The Ring Two but left the film due to "creative differences".

[6] In 2012, he directed advertising campaigns for well-known brands such as Adidas, Nike, eBay, Volkswagen, Land Rover, Toshiba, Stella Artois and many others.

[5] In 2008, Murro made his directorial debut with Smart People, a comedy presented at the 2008 Sundance Film Festival.