Nob Hill is a neighborhood in Albuquerque, New Mexico, United States, consisting of a commercial district along Central Avenue (former U.S. Route 66) and surrounding residential areas.

Known for its eclectic mix of mostly locally owned businesses, Nob Hill has been described as "the heart of Albuquerque's Route 66 culture and also its hippest, funkiest retail and entertainment district".

[6] A photograph from 1937 shows Sellers posing with a large "Nob Hill" sign in an empty expanse of desert near what is now Silver and Tulane SE.

Due to topography and drainage concerns, the streets were laid out in an irregular pattern around two intersecting diagonal boulevards, Campus and Monte Vista.

[8] Nob Hill's commercial strip began to develop in the 1930s, spurred both by the growth of the surrounding neighborhoods and by the increasing number of travelers on Central Avenue.

The tourist business similarly suffered when Interstate 40 was completed, providing travelers a faster and more convenient route through the city that bypassed Central.

A number of buildings were added to the National Register of Historic Places in the 1980s and 1990s, and by the mid-1990s the neighborhood's commercial core was thriving and property values were on the rise.

In recent years, city planners have focused on expanding redevelopment efforts to the previously blighted Upper Nob Hill and Highland areas.