[2] She began her career at the age of nineteen where she did a lot of children's and educational theatre productions that toured South Africa and the UK.
In 2009, she was nominated as the Best Supporting Actress during the 3rd South African Film and Television Awards (SAFTAs).
[citation needed] She also played supportive roles in the serials Hard Copy, Backstage, Umlilo and Scandal!.
[4] In the remake of original 1977 version of American mini-series Roots, Nokuthula played a lead role as 'Kunta Kinte's mother'.
[5] In the e.tv drama series Umlilo, she starred the role as 'Dumile', a city girl born and raised in Soweto who is the second wife in a polygamous marriage.