The show, which was created by Georden Whitman, is a western-fantasy hybrid focused on a mute wanderer hunted for being capable of using magic to give life to inanimate objects.

[3] On January 17, 2018, Collider published an article about the show, describing it as a "western adventure that takes cues from Samurai Jack," quoting show director Jordan Cwiecz as describing it as a "western/fantasy mash-up about a mysterious nomad traversing a western wasteland that hasn’t seen magic in 100 years," saying that people should think of it "as two-parts Samurai Jack and True Grit with just a dash of The Lord of the Rings" with humor, fun, and much more.

[17] He also said that his main source of inspiration came from live-action drama like spaghetti westerns and Deadwood, which have nostalgia and themes of despair in harsh lands with hard lives.

[23] Padraig Cotter of Screen Rant described the show as a "mixture of fantasy and western" with a "quirky sense of humor and blend of genres," saying it has earned a loyal fanbase, and even said that some compared it to Trigun and Samurai Jack.

[28] On July 11, 2020, on an episode of the podcast Talk CRWBY to Me, Miles Luna revealed writer Kiersi Burkhart originally joined Rooster Teeth to work on Season 2 of Nomad of Nowhere and the process went "pretty far along," but production was halted when it was decided continuing the series at the time was not advisable.