Nong Khae (Thai: หนองแค, pronounced [nɔ̌ːŋ kʰɛ̄ː]) is a district (amphoe) in the southern part of Saraburi province, central Thailand.

Nong Khae has the Na Roeng khlong (canal) that connects to the Pa Sak River.

The Ayutthaya Kingdom army moved their troops by this canal for military purposes.

Recently there has been immigration of people from Lan Na and Vientiane to this district.

There are three municipal (thesaban) areas, and a further 16 tambon administrative organizations (TAO).