[7] Mukiele gained attention while playing for Laval and eventually transferred to Montpellier for a fee of €1.35 million.

[11] He made his debut for the club on 26 July 2018, in a UEFA Europa League qualifier against Häcken that ended as 4–0 win.

[14] During the 2021–22 season with RB Leipzig, he participated in his team's DFB-Pokal Final victory over SC Freiburg, the first trophy of his career.

[15] On 26 July 2022, Mukiele signed for Ligue 1 club Paris Saint-Germain (PSG) on a five-year contract until 30 June 2027.

[20] Mukiele received his first call up to the senior France squad for FIFA World Cup qualification in September 2021.