"[14] Schick spent most of his spell at Roma playing out on the right wing or left up front by himself, and he scored only eight times in 58 games.

[14] On 2 September 2019, Bundesliga club RB Leipzig announced the signing of Schick on a season-long loan deal with an option to buy him permanently.

[16] This started a run of three goals in four league appearances including coming off the bench to complete the comeback and secure a 3–3 draw with Borussia Dortmund.

[3][17] Alongside Timo Werner, Schick rekindled his form with 10 goals in 28 games for Leipzig as the club finished in third place in the Bundesliga and reached the semi-finals of the Champions League.

[14][18] On 8 September 2020, Schick joined Bayer Leverkusen on a five-year contract for a reported fee of €26.5 million plus bonuses, getting the number 14 on his jersey.

[19][20][21] Schick scored his first goal in a UEFA competition on 26 November 2020, coming in a 4–1 victory over Israeli club Hapoel Be'er Sheva in the group stage of the Europa League.

[47] In March 2024, Schick scored three critical goals to keep Bayer Leverkusen in the Europa League in their round of 16 tie against Qarabağ FK.

[49] On 30 March, he scored a stoppage-time winner in a 2–1 victory over Hoffenheim, which secured his club's qualification for the 2024–25 UEFA Champions League group stage on matchday 27.

[50] On matchday 32 against Eintracht Frankfurt, Schick scored a header in a 5–1 victory for Leverkusen to extend their 48-game unbeaten streak.

[51] In matchday 33 against Vfl Bochum, Schick scored the opening goal of a 5–0 Leverkusen win, making history as the club's 50th game unbeaten.

[61] Schick was called up to the Czech Republic senior side for the first time at their pre-UEFA Euro 2016 training camp.

[5] He made his national team debut in a friendly match against Malta on 27 May 2016, scoring after coming on as a second-half substitute in a 6–0 victory.

[63] In the first group stage match against Scotland on 14 June at Hampden Park in Glasgow, Schick scored both goals as the Czech Republic won 2–0.

[67][68] He became the first Czech player since Tomáš Rosický at the 2006 FIFA World Cup to score a brace at a major tournament and the first since Milan Baroš in 2004 to do so at the European Championship.

[71] On 3 July, he scored in a 2–1 controversial defeat against Denmark in the quarter-finals, to equal Milan Baroš' record of five goals for the Czech Republic in a European Championship tournament.

[74] In the 2022 World Cup Qualifiers against Belarus, Schick scored and provided Hlozek's first goal for the national team, and it ended a comfortable 2-0 win.

[78] In the nation's final warm up game before the Euros, against North Macedonia on 10 June 2024, Schick had a goal ruled offside,[79] but went on to score from the penalty spot in a 2–1 win for the Czechs.

[80] In the tournament he scored the equaliser against Georgia in a 1–1 group stage draw, which was also his 20th goal for the national team,[81] only to suffer from a calf injury ten minutes later.