Their sound has been compared to bands such as Bauhaus, Sonic Youth, The Cure, Bailter Space, Swervedriver, The Psychedelic Furs, My Bloody Valentine and Psi Com.
Plexi's material combined a mix of detached, wry, existential, and romantic lyrics with a flamboyant blend of glam rock and artsy avant-garde textures and noise.
A blurb on the band in the 1997 CD Spring Lineup: A Compilation Of Sub Pop's Heavy Hitters read, "Embraced by the hardest rock enthusiasts and real favorites at the Viper Room, Plexi is L.A.'s freshest Noxema [sic] girl."
The EPs attracted attention from larger independent labels, culminating in their "discovery" by a friend of Sub Pop band Sunny Day Real Estate, Curtis W. Pitts.
In an interview with Alternative Press magazine in Nov. 1996, Angelos professed his fandom of Aldous Huxley and David Bowie; upon being asked if Plexi's music might send the wrong message to suicidal listeners, Angelos laughed and responded, "Well, as long as I don't die..." Plexi then toured with bands such as Bare Minimum, Zeke, Jack Off Jill and Ednaswap, and played at an ESPN X Games qualifying competition in New Orleans.
Angelos would later collaborate with Dave Navarro on the Joy Division tribute track "Day of the Lords" under the outfit name Honeymoon Stitch.
There was some suggestion by Navarro the recording session was complicated by substance abuse issues and their vocalist's inability to stay conscious and standing.
Block drummed in Jack Off Jill for a while, then formed the Plexi-esque band Tape with future She Wants Revenge leader Justin Warfield.