[1] Mitchell appeared in Broadway comedies, including The Call of the Cricket (1910), The Truth Wagon (1912),[2][3] Her Husband's Wife (1917),[4] March Hares (1921), To the Ladies (1922), The Goldfish (1922), Why Not?

She also acted in the films The Woman Accused (1933),[5] Melody in Spring (1934), and Susan and God (1940).

[1] Mitchell wrote Cradle Snatchers (1925) with Russell G. Medcraft,[6] a comedy starring Mary Boland, Edna May Oliver, and a young Humphrey Bogart;[7] it was adapted for the screen three times, as Cradle Snatchers (1927), as Why Leave Home?

[10] Mitchell also wrote a sketch, "Her Morning Bath", made popular in 1926 by vaudeville star Charlotte Greenwood.

[18] Her first husband was journalist and playwright Hayden Talbot, father of editor Betsy Blackwell; they married in 1913 and divorced in 1921.