While President of USC, Topping announced an ambitious "Master Plan for Enterprise and Excellence in Education."
As part of the execution of the plan, USC's University Park Campus grew from 95 to 150 acres.
[1] Also during Topping's presidency, USC joined the Association of American Universities an important symbolic step toward USC's increasing recognition as a top tier research university.
Topping was an BA and MD alumnus of USC and worked at the U.S. Public Health Service on the typhus vaccine used in World War II by more than fifteen million United States, Canadian, and British soldiers, a treatment still in use today.
Later he helped develop the first effective treatment against Rocky Mountain spotted fever.