Normandie Avenue is one of Los Angeles County's longest north–south streets, with a stretch of about 22.5 miles (36.2 km).

Through traffic on Normandie is directed onto Irolo Street between just north of Olympic Boulevard and Wilshire Boulevard; in this section, Normandie exists as a small residential street.

After crossing Franklin Avenue, Normandie resumes as a residential street before reaching its northern terminus at Ambrose Avenue in the Los Feliz district of Los Angeles.

The intersection of Florence and Normandie is noted for its involvement in the 1992 Los Angeles riots.

A subway station is served by the Metro D Line at its intersection with Wilshire Boulevard.