North Avenue station was planned as part of the Phase 1 of the EDSA LRT III project, following a Build-Lease-Transfer (BLT) agreement between the Department of Transportation and Communications (DOTC) and EDSA LRT Corporation on September 22, 1992.

[2][3] Construction finally began on October 15, 1996 as the MRT III project, under a BLT contract awarded to the Metro Rail Transit Corporation (MRTC), led by a consortium of local companies.

Other nearby landmarks include the Veritas Tower (home to the Veritas 846 studios), SM Cyber West Avenue, Philippine College of Surgeons, UNTV Broadcast Center, and Triangle Park, where Veterans Memorial Medical Center, Vertis North, Ayala Malls Vertis North, Philippine Science High School Main Campus, Quezon City Science High School, and Ninoy Aquino Parks & Wildlife Center are located.

The Philippine Medical Association secretariat, Phil-Am, and Sogo Hotel North EDSA are also within reach of the station.

Taxis, jeepneys, minibuses, and UV Express vans also stop in the vicinity.