North Carolina Highway 45 (NC 45) is a primary state highway in the U.S. state of North Carolina.

The highway traverses north–south, from Ocracoke to Winton.

NC 45 starts at the ferry terminal at Ocracoke, connecting with NC 12, it traverses across the Pamlico Sound along the Swan Quarter-Ocracoke Ferry.

North of Plymouth, it parallels west of the Chowan River before reaching its northern terminus at US 13/US 158, near Winton.

On May 1, 2013, NC 45 was extended south from Swan Quarter to its current southern terminus in Ocracoke, crossing over the Pamlico Sound along the Swan Quarter-Ocracoke Ferry.