North Carolina Highway 66 (NC 66) is a 47.0-mile (75.6 km) North Carolina state highway that travels from Horneytown to Johnstown, connecting the towns and communities of eastern Forsyth and Stokes counties.

Once NC 66 reaches Rural Hall, it runs parallel to US 52 until King.

South of King NC 66 heads north towards Gap.

The highway then runs through the mountains of curvy roads until reaching its northern terminus at a Y-intersection with NC 89.

NC 66 then headed north along today's University Parkway to Stanleyville.

In 1925, NC 66 was rerouted to follow Patterson Avenue into Winston-Salem.

It traversed from US 421/NC 60 (Liberty Road), in Greensboro, going southeast through Climax, Franklinville, Ramseur, Coleridge and Bennett, to NC 74 (today NC 24/NC 27), west of Carthage.