It serves the Foothills and Piedmont Triad areas of the state, connecting the cities of Shelby, Mooresville, Salisbury and Winston-Salem.

After crossing into Cleveland County, the route travels through Waco and across a small part of Kings Mountain Reservoir.

NC 150 continues past the power plant through the lake-oriented communities of Terrell and Sherrills Ford, crossing over numerous tributaries of the lake/Catawba River.

This stretch of road has witnessed massive growth in the early 2000s (decade) with the construction of numerous big box stores as a result of the growing popularity of nearby Lake Norman and the local NASCAR racing culture.

In the late 2000s, I-85 received a new Yadkin River crossing, which also eliminated the awkward left exit and entrance for NC 150 and US 29/70.

Near the Churchland community, NC 150 takes an odd turn east, despite being signed west, toward I-85/US 29/70/52 to avoid crossing the Yadkin River.

When entering Forsyth County, Peters Creek Parkway carries NC 150 using the partial controlled access grade with a speed limit of 55 mph (89 km/h).

It then passes a diamond interchange with Clemmonsville Road, before downgrading to a four-laned boulevard with a speed limit of 45 mph (72 km/h).

Using Macy Grove Road, NC 150 effectively bypasses downtown Kernersville using a parkway grade with a speed limit of 45 mph (72 km/h).

NC 150 leaves Macy Grove Road at an intersection with Main Street shortly before entering Oak Ridge.

NC 150, remaining a two-lane route, continues westward again, through the small community of Monticello, before coming to an interchange with Future Interstate 785 (I-785) and US 29.

Slowing to a 35 mph (56 km/h) speed limit after the interchange, NC 150 progresses towards Browns Summit, the first of three northern Greensboro suburbs the route passes through.

After passing through a small road kink at a railroad crossing in the middle of Browns Summit, the route makes its way entirely across the rural community, thereby effectively bypassing Greensboro and remaining north of the county.

NC 150 enters Summerfield's commercial district, at the US 220 and Auburn Road junction, where a handful of shopping centers can be found, and then turns right and shares a short 1.3-mile (2.1 km) concurrency with US 220 northbound.

In concurrency, it goes through downtown area via Main Street and Court Square Drive before linking back with NC 150 at Generals Boulevard.