North Dakota Highway 46 (ND 46) is a 121-mile-long (195 km) road in eastern North Dakota, crossing the Red River Valley between Streeter and Oxbow.

It parallels and runs about 20 miles (32 km) south of Interstate 94 (I-94).

29.7 miles to the east, it intersects ND 1 outside of Litchville, and meets ND 32 on the Ransom/Barnes county line.

The two run concurrent for six miles before ND 32 turns south and ND 46 continues due east.

3 miles to the east, it passes the first road providing access to Enderlin, ultimately connecting with ND 18, 17.7 miles to the east.