It runs from South Dakota Highway 63 in McLaughlin to Interstate 94 Business Loop in downtown Mandan.

A sign that the highway is approaching its northern terminus is when it passes the Mandan Municipal Airport.

The highway doesn't officially enter Mandan, until roughly around 19th Street, and from there it passes by a United States Department of Agriculture (USDA) lab, and a local youth corrections center.

It then crosses a bridge over the Heart River, where on the other side it becomes 10th Avenue and cuts through the Mandan Municipal Golf Course.

Immediately after a bridge over the BNSF Railway (BNSF) Mandan Rail Yard, ND 6 ends at Interstate 94 Business Loop (BL 94), although 10th Avenue continues northbound as a local residential city street.