Along with the rest of Detroit, it experienced a cultural and economic boom in the 1920s and 1930s due to the success of the automotive industry, and the district continued to experience growth.

I-75 was built in 1959, dividing the North End from the city center and also destroying the African American neighborhoods of Paradise Valley and Black Bottom.

Marygrove College professor Frank D. Rashid has noted that Detroit's vibrant entertainment district Paradise Valley had eventually stretched as far as the North End.

[14][15] In 2006, the North End was chosen as one of six target areas for $100m funding from The Skillman Foundation, a grantmaking charitable body that focuses on improving the lives of Detroit's children.

On March 14, 2016, the Michigan Humane Society opened its new and expanded $15.5 million animal care campus on five acres, including a 35,000 square foot, state-of-the-art veterinary facility, located just east of New Center at 7887 Chrysler Drive near Clay Street.