North Fort Myers High School offers AICE, Advanced Placement, Dual Enrollment, Vocational, Honors and general education classes, in addition to its Arts & Media program and the North High Collegiate Academy.

Students who complete the requirements of the program will earn a Cambridge AICE diploma, and are automatically eligible for the maximum Florida Bright Futures scholarship.

[10] Incoming freshmen have the opportunity to attend an orientation camp in August, where students learn about North High programs, clubs, and school traditions.

The administration of the school resisted, even pretending not to recognize a black basketball coach and directing the police to attack him with dogs.

[12] In 2008, North Fort Myers High School was awarded a grade of "A" by the Florida Department of Education.

[12] The 2007–08 academic year marked the first time in school history that North High had received an "A" rating.

This program is a four-year sequence of project-based courses oriented to game and simulation development that align relevant academic, employment, and workplace standards.

Through its courses in Accounting Applications, Computing for College and Careers, Administrative Office Technology, Digital Design, and Cooperative Business Education, instruction is provided that helps the students meet the many challenges in today's society.