He played in Major League Baseball (MLB) for the Baltimore Orioles, Colorado Rockies, Oakland Athletics, and New York Yankees.

[2] On January 12, 2007, Miller was traded to the Baltimore Orioles alongside minor league pitcher Jason Burch in exchange for Rodrigo López.

[3] He was called up on September 1, 2008, to the Orioles,[4] and made his major league debut against the Boston Red Sox on the same day, allowing one unearned run and two walks in two-thirds of an inning.

[9] He made his Athletics debut on April 25, 2012, against the Chicago White Sox, and was the winning pitcher in that game.

[12] On September 7, 2013, he gave up the first career home run to Boston Red Sox shortstop Xander Bogaerts.