In the late 1960s the present station building was constructed; in 1993 a travel centre was built, that replaced the traditional ticket counters.

On 15 November 1992 at 1:30 am there was an accident in the immediate vicinity of Northeim station that resulted in 11 deaths and 51 injuries.

Since the timetable change of 2009/2010 in December 2009 the number of Intercity trains calling at Northeim were significantly reduced.

The majority of IC services run instead on the Hanoverian Southern Railway on the Hanover–Wurzburg high-speed line.

Three pairs of Intercity trains remain in the Leine valley and stop, as was normal until 2009, in Alfeld, Northeim and Kreiensen.