The airport opened as Muscle Shoals Auxiliary Field in February 1940, but in 1942 it was taken over by the United States Army Air Forces, as a World War II pilot training military airfield.

Under federal law, Delta Connection must continue service to Muscle Shoals until a replacement carrier is found.

[3] In 2011, Air Choice One, a Missouri-based carrier, submitted a proposal to the US DOT to serve Muscle Shoals with flights to either Atlanta, Nashville or Memphis.

Southern merged with North Central to form Republic, which continued at Muscle Shoals with DC-9-50s to Atlanta and with Convair 580s and Metroliners to Memphis.

Due to constant delays and cancellations, ridership declined to about 3 passengers per day under Silver, below EAS guidelines.

SeaPort Airlines announced it would take Silver's place in the Fall of 2014,[5] and began daily flights to Nashville and Memphis on January 12, 2015.

[1] In the year ending May 31, 2021, the airport had 36,805 aircraft operations, averaging 101 per day: 88% general aviation, 7% airline, 1% air taxi and 4% military.