The league operated as the High-A West in 2021, then resumed its original moniker in 2022.

In 1955, the Northwest League was formed, with seven charter teams: Salem Senators, Eugene Emeralds, Yakima Bears, Spokane Indians, Tri-City Braves, Wenatchee Chiefs, and Lewiston Broncs.

[4][5] The league switched to the short season schedule in 1966;[6] between then and 1982, the NWL fluctuated between four, six, and eight clubs.

The start of the 2020 season was postponed due to the COVID-19 pandemic before ultimately being cancelled on June 30.

Eight alumni of the Northwest League are enshrined in the Baseball Hall of Fame: