The Northwestern Hotel is a historic building located in the East Village of Des Moines, Iowa, United States.

[1] In 2017 it was included as a contributing property in the East Des Moines Industrial Historic District.

[2] Opening in 1916, the Northwestern Hotel was built to serve the needs of railroad employees and passengers from the nearby Chicago and North Western depot, and other people of modest means.

Eventually, the building went into a slow period of decline before Polk County officials forced it to close in 1982.

[4] The building was designed by the prominent Des Moines architectural firm of Proudfoot, Bird & Rawson.