It was affiliated with the (Lutheran) Norwegian State Church and existed from 1867 until it merged with other organisations to form Normisjon in 2001.
The Norwegian Santal Mission has operated schools and hospitals in India and Bhutan.
The organisation was the Norwegian branch of the Santal Mission of the Northern Churches, that was established by the Norwegian missionary Lars Olsen Skrefsrud and the Danish missionary Hans Peter Børresen.
Notable people affiliated with the Norwegian Santal Mission include Olav Hodne.
Prior to 1883, the Norwegian Santal Mission consisted of local committees and lacked a national leadership.