Nossville is an unincorporated area in Tell Township, Huntingdon County, Pennsylvania.

It is located on the banks of Tuscarora Creek, a tributary of the Juniata River.

The settlement was named after Colonel George Noss (1813-1892), who built a steam tannery there in 1848.

The tannery burned down in 1870, was rebuilt under new ownership, closed in 1878, but was reopened in 1881 by Oswill Mosser (1854-1896).

Noss was also involved in an attempt to build a railroad in the area, initially called The Duncannon, Landisburg, and Broad Top Railroad Company; incorporated in 1854,[2] it never built track and the charter became dormant in 1879.