Notch family members play a role in a variety of developmental processes by controlling cell fate decisions.

In Drosophila, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development.

This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer.

This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development.

[8] Mutations within the last coding exon of Notch2 that remove the PEST domain and escape the nonsense-mediated mRNA decay have been shown to be the main cause of the Hajdu–Cheney syndrome.