The song was originally recorded by Michaels himself; however, he was working with Miley Cyrus who asked to sing on the track with him.

[1] Miley Cyrus covered the hit Poison ballad "Every Rose Has Its Thorn" with Michaels for her album Can't Be Tamed and then became involved on Bret's new single.

"Nothing to Lose" is a country rock ballad, backed mostly by acoustic guitar.

He said that Michaels lures in listeners with a suggestive passage about getting sexy to save a faded love.

[2] Bret Michaels performed 'Nothing to Lose' live with an acoustic guitar on "Lopez Tonight" and witnessing the audience's reaction to Michaels heartfelt performance, George Lopez closed with "That's how real rockers do it".