The division produces a flagship nightly early-evening newscast, Noticias Telemundo, focusing on international news and stories of relevance to the network's main target demographic of Hispanic and Latino Americans.

In 1992, Enrique Gratas joined the network to serve as anchor of Ocurrió Así, a nightly newsmagazine providing in-depth stories dealing with issues pertinent to U.S. Hispanics and investigative reports.

In 1994, Telemundo launched its own 24-hour cable news channel, Telenoticias, which was operated as a joint venture between Argentinean television network Artear, Spain broadcaster Antena 3 and Reuters.

Following the sale of Telenoticias to CBS, Telemundo entered into a content partnership with the channel to produce early-evening and prime time newscasts that would air on the broadcast network.

In 2002, the network launched a late afternoon news and entertainment magazine series, similar in format to its Univision competitor Primer Impacto, Al Rojo Vivo con Maria Celeste.

In 2007, Telemundo discontinued the Saturday and Sunday editions of the flagship Noticiero Telemundo broadcast and Al Rojo Vivo, which were replaced with feature films and reality-based series (with the move, Univision became the only Spanish-language broadcast network to carry a weekend edition of its evening newscast and the only one carrying any non-sports news programming on weekends altogether); weekend editions of Noticiero Telemundo were restored on October 4, 2014, focusing on general news, health and consumer segments, analysis of the previous week's major stories and a preview of events occurring in the coming week (which was scheduled 90 minutes earlier than the flagship weeknight editions, at 5:00 p.m. Eastern and Pacific Time, to accommodate the network's prime time entertainment programming).

[11] Cada Dia was cancelled in May 2008, after Collins announced that she would leave Telemundo when her contract expired in August of that year return to news anchoring and as a result of low ratings for the program;[12] Noticiero Telemundo: Madrugada, meanwhile, was replaced by an hour-long music and dance program that was spun off from the network's Saturday afternoon series Descontrol.