Notre-Dame-des-Bois (French pronunciation: [nɔtʁə dam de bwa]) is a municipality in Le Granit Regional County Municipality in the Estrie region of Quebec, Canada, on the Canada–United States border.

Located in the Appalachians, it lies at 555 metres in altitude, making it one of the highest towns in Quebec.

Mont-Mégantic National Park is located in Notre-Dame-des-Bois and is one of the biggest tourism draws to the region.

The Mont-Mégantic National Park is located in this municipality.

On top of Mont Mégantic is located Mont Mégantic Observatory which houses the second largest telescope in Eastern Canada.