Situated on a hill, the school originally comprised several buildings, one of which is Harugari Hall (now in the possession of the neighboring University of New Haven).

Announced in 2007, the new 28,000-square-foot Arts, Technology, and Spiritual Center was officially opened for the 2012–13 academic school year.

On April 3, 2024, the school announced that it will shift to a co-education model and will begin enrolling girls in fall 2025.

[4] Located in the Roman Catholic Archdiocese of Hartford, Notre Dame is operated independently by the Congregation of Holy Cross.

Known as the "Green Knights," Notre Dame High School's athletes boast a rich tradition of success with notable football, ice hockey, baseball, tennis, golf, basketball, swim, and track programs.