It is run by the Apostles of the Sacred Heart of Jesus, an order of religious sisters founded in Italy by Mother Clelia Merloni.

Initially located in New Haven, Connecticut, the school was established to provide a Catholic college preparatory education to local young women.

The school has continued to expand throughout the years, adding classrooms, computer labs, and recreational facilities as needed.

Each season, students can choose from a variety of sports teams, including field hockey, volleyball, soccer, swimming, cross country running, and cheerleading in the fall, basketball and indoor track in the winter, and lacrosse, softball, tennis, and track and field in the spring.

Each year since 1998, students enrolled in biotechnology classes have worked on advanced research projects and have presented their findings at a national conference.

[5] Following their successes, another group of students continued their project, submitting additional sequences for the calcitonin and vitamin D receptors in Bos taurus and presenting their findings at the Annual Conference sponsored by American Society of Human Genetics in New Orleans, Louisiana.

These accomplishments helped make Sacred Heart the recipient of a grant from the John G. Martin Foundation of Farmington for a molecular science research laboratory.