[2] The Novi Sad Synagogue was added to Spatial Cultural-Historical Units of Great Importance list in 1991, and it is protected by Republic of Serbia.

[3] The former synagogue became a major project for the entire Jewish community of Novi Sad, on which construction began in 1905 and was completed in 1909.

Projected by Hungarian architect Lipót Baumhorn, it was part of a bigger complex of buildings that included, on both sides of the synagogue, two edifices decorated in a similar pattern; one building served as the Jewish school and other as offices of the Jewish community, including a mikvah, slaughterhouse, school, retirement home, and an orphanage.

The three-aisled main sanctuary space is topped by a 40-metre (130 ft) high Renaissance-inspired dome with stained glass in its cupola.

Approximately 1,000 Jews from Novi Sad survived the Holocaust that followed the German invasion of Yugoslavia in 1941 and the annexation of Bačka region by Hungary.