Noxiustoxin

[6] It was the second purified toxin obtained from the genus Centruroides after neurotoxin II[8] and the first short peptide from scorpion venom to be reported in the literature.

[9] The name for noxiustoxin was first proposed in 1982,[2] before which it was known as toxin II-11[9] NTX is a peptide consisting of 39 amino acid residues.

[10] The three-dimensional solution structure of NTX has been solved by nuclear magnetic resonance (NMR).

[12] In the squid axon, NTX was found to have relatively low binding affinity with their target site on the channel protein (KD = 300nM).

[16] Intoxication symptoms of mice include hyperexcitability, lacrimation, convulsions, salivation, dyspnea, and eventually death by respiratory paralysis.

3D molecular structure of noxiustoxin.