Noxubee County is solidly Democratic in modern presidential elections, having last voted for the Republican nominee in 1972.

In the final presidential contest before the act's passage, the 1964 election, anti-civil rights whites in Noxubee gave 96.6% of the county's vote to Republican Barry Goldwater — a margin no candidate of either party has surpassed in any county in any subsequent presidential election.

[13] The Noxubee County Sheriff's Department has been embroiled in controversies related to covering up rape and abuse at its facilities.

In 2023, former sheriff Terry Grassaree faced criminal charges for his involvement in rape cases.

[16] Noxubee County is within the service area of the East Mississippi Community College system.

In the early 20th century, 19 of these were consolidated into two districts consisting of six schools, which were Salem, Lynn Creek, Center Point, Cliftonville, Cooksville-Paulette, Mashulaville, and Brooksville.

[19] The Noxubee County Agricultural School at Mashulaville opened in 1910 and included a 40-acre farm and provided living arrangements for up to 40 boarding students.

[23] In 2005, the U.S. Department of Justice began an investigation and the following year filed suit under the Voting Rights Act alleging that the chairman of the Noxubee County Democratic Party, Ike Brown, had conspired to orchestrate "relentless racial discrimination" against White voters.

[24][25] The court ruled that Brown, in conjunction with the Noxubee Democratic Executive Committee, had "manipulated the political process in ways specifically intended and designed to impair and impede participation of White voters and to dilute their votes".