Nucleic acid templated chemistry

The oligonucleotides recognize specific nucleic acids and are hybridized sterically close to each other.

In 1999 Pavel Sergeev suggested the use of NATC to synthesize biologically active compounds within living organisms.,[1] including use within human cells.

In this application, the precursors are distributed in the whole human body and the chemical reactions are performed only within cells having specific RNA molecules.

Many scientific groups have performed NATC in vivo to visualize eukaryotic as well as bacterial cells.

As a principle, it may be employed to treat oncological and bacterial diseases, as well as to visualize them.

The schematic presentation how the nucleic acid templated chemistry works within cells
Schematic presentation of chemical reaction within cells to combine two precursors into an active drug