[3] Injury to the nucleus prepositus results in inability to hold gaze upon a visual target; conjugate eye movement is unaffected.

[4] It is continuous rostrally with the paramedian pontine reticular formation,[1] and caudally with the intercalated nucleus.

[2] It receives afferents from the frontal eye fields, medial and dorsal vestibular nuclei, paramedian pontine reticular formation, and interstitial nucleus of Cajal.

[2] The nucleus prepositus integrates velocity-position information for horizontal eye movements to enable eccentric gaze.

[6] Tonic neurons of the nucleus (along with those of with the medial vestibular nucleus) are believed to maintain eccentric (i.e. off resting position) direction of gaze, counteracting forces pulling the eye back to its default, resting, straight-forward gazing position after saccades.