Mexicana Universal San Luis Potosí is a pageant in San Luis Potosí, Mexico, that selects that state's representative for the national Mexicana Universal pageant.

The State Organization hasn't had a national winner in Nuestra Belleza México.

Below are the names of the annual titleholders of Mexicana Universal San Luis Potosí, listed in ascending order, and their final placements in the Mexicana Universal after their participation, until 2017 the names are as Nuestra Belleza San Luis Potosí.

As of 2000, isn't uncommon for some States to have more than one delegate competing simultaneously in the national pageant.

The following Nuestra Belleza San Luis Potosí contestants were invited to compete in Nuestra Belleza México.