It is located in the northwestern part of the state of Chihuahua, on the Casas Grandes or San Miguel river, situated in a wide, fertile valley on the 4,000-foot Mesa del Norte of the Plateau of Mexico.

Nuevo Casas Grandes is also world-famous for the nearby "potter village" of Mata Ortiz an ejido and its revival of pottery in the ancient Paquimé tradition.

As Nuevo Casas Grandes has grown in the last few decades, it now meets on the north side with the Mormon colony, Colonia Dublán.

Many who reside near Nuevo Casas Grandes endeavor to maintain orchards which grow a variety fruits, including peaches, apples, pears, and pecans.

[citation needed] The city is served by the Nuevo Casas Grandes Municipal Airport (IATA: NCG, ICAO: MMCG).