Nukleuz has been the home of some of the world's greatest and most respected hard dance stars including BK, Andy Farley, Nick Sentience, Mauro Picotto, Mario Piu, Lisa Pin-Up, Stu Allan, Alphazone, Tom Harding, Phil Reynolds, Organ Donors, Breeze & Styles, Pierre Pienaar, Disco Brothers and more.

The label has recently been successful in producing new talent in the hard dance scene, with such artists as Andy Whitby, Cally & Juice, P.H.A.T.T., Technikal, Dark By Design and Gammer.

Besides Nukleuz's own collective of artists, the label has also licensed a number of tracks from other parts of the world, resulting in them being UK chart-toppers.

Notable examples of this are the 2000 re-issue of Belgian techno artist Praga Khan's rave anthem "Injected with a Poison" and Mauro Picotto's "Lizard", which was a top 30 hit in the UK.

The label has two of their megamixes make the UK singles chart under the collaborative name "Nukleuz DJs"; the tracks were both entitled "DJ Nation".