The first major segment of the film introduces the poor Mancuso family (headed by the widowed Salvatore, Vincenzo Amato), from Sicily, Italy, at the turn of the 20th century residing in a rural mountainous region, who decide to emigrate to the United States after receiving a sign from God in the form of American postcards depicting giant produce and chickens.

Their dreams about the land of opportunity where giant vegetables are grown, people swim in milk, and coins fall from the sky propel their decision, which gives the viewer insight into the unrealistic expectations that many immigrants held about America.

Salvatore takes his family consisting of his two sons as well as his old mother, Fortunata, who we learn is the village folk healer and involved heavily in mysticism (Aurora Quattrocchi).

Their complex relationship highlights the troubling dynamic of the time, as women must still submit to male authority in the new world in order to even hope for the lesser freedom they so desire.

At Ellis Island, the final major segment of the film, the family join the rest of the immigrants on board to undergo extensive and humiliating physical and psychological examinations and questioning.

The website's critical consensus states: "Slow-moving but ultimately rewarding, Golden Door is a profound drama with scenes of fantastical magical realism, lively humor, and stunning images" .