Nyctimystes trachydermis, also known as the Morobe big-eyed treefrog, is a species of frog in the subfamily Pelodryadinae of the family Hylidae.

[1][3] Its type locality (which it shares with Nyctimystes tyleri[2]) is Gapaia Creek, at 1,280 m (4,200 ft) asl between Garaina and Saureli, in the Morobe Province.

[2][3] The specific name trachydermis means "rough skinned", derived from the Greek words trachys and derma.

[2] Nyctimystes trachydermis are relative large frogs, with adult males measuring 72–88 mm (2.8–3.5 in) in snout–vent length.

[2] Nyctimystes trachydermis live along small streams in montane rainforests at elevations of 1,280–2,480 m (4,200–8,140 ft) above sea level.