The first village located on what is now the Nyzhniodniprovskyi District was founded in the late 16th century, making the area one of the oldest inhabited parts of Dnipro.

[1] According to historical findings on the current territory of the Amur-Nyzhniodniprovskyi District there was a village called Kamianka that was founded in 1596.

[1] After the liquidation of Zaporizhian Sich by the Russian government of Catherine the Great in 1775, the region was admitted into the newly formed Novomoskovsk county of Yekaterinoslav Governorate.

[1] In September 1917 all settlements of Zadniprovia were organized into a district of Zadniprovskyi Raion.

[1] In World War II the area saw heavy fighting during the June 1941 phase of Operation Barbarossa.