O'Kean is a town in Randolph County, Arkansas, United States.

O’Kean was settled before the Civil War, and is named for the priest of the St. Paul’s Catholic Church, Father James O’Kean, who frequently stopped in the community en route to nearby Pocahontas.

With the construction of the St. Louis, Iron Mountain and Southern Railway in the 1870s, O’Kean expanded rapidly.

A railroad tie manufacturing operation was among the businesses established in the city during the period.

According to the United States Census Bureau, the town has a total area of 2.6 km2 (1.0 mi2), all land.

[8] In 2007 the Greene County district closed Delaplaine Schools and redirected O'Kean students to the campuses in Paragould.